Brewers vs. Cardinals odds, prediction, line: 2026 MLB picks for May 6 matchup from proven

AAS Editorial Team

Brewers vs. Cardinals odds, prediction, line: 2026 MLB picks for May 6 matchup from proven

Game Overview

The Milwaukee Brewers meet the St. Louis Cardinals in the final game of their rain-shortened two-game National League Central Division series on Wednesday afternoon. St. Louis earned a 6-3 win on Monday, before Tuesday's game was postponed by inclement weather.

First pitch from Busch Stadium in St. Louis is set for 1:15 p.m. ET.

Team Records

The Brewers (18-16) have won three of five and are 8-8 on the road this season. The Cardinals (21-14) have won seven of eight and are 10-9 on their home field in 2026.

Starting Pitchers

Brandon Sproat (0-2, 6.75 ERA) is scheduled to start for Milwaukee, while St. Louis will start Andre Pallante (3-2, 3.73 ERA).

Injury Report

Milwaukee is without outfielder Christian Yelich (groin).

Betting Odds

Milwaukee is a -111 favorite on the money line (risk $111 to win $100). The over/under is set at 8.5 runs.

Prediction

After 10,000 simulations of Brewers vs. Cardinals, the model is going Over 8.5 combined runs. The Over has hit in five of the last 10 St. Louis games. Milwaukee is eighth in runs scored with 175, while the Cardinals are ninth with 172.

The model projects 9.6 combined runs as the Over hits in 59.1% of simulations.

Player Projections

SportsLine's model projects over 1.6 total bases for the Brewers' Garrett Mitchell, Jackson Chourio, Brice Turang, William Contreras, and Jake Bauers. The Cardinals are projected to get over 1.5 total bases from Alec Burleson, Jordan Walker, and Ivan Herrera.

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