Red Sox vs. Tigers odds, prediction, line: 2026 MLB picks for May 5 matchup from proven

AAS Editorial Team

Red Sox vs. Tigers odds, prediction, line: 2026 MLB picks for May 5 matchup from proven

The Detroit Tigers look to bounce back after a tough Monday when they host the Boston Red Sox in the second of a three-game set on Tuesday's MLB schedule. Detroit (18-18) not only lost 5-4 to Boston yesterday, but the Tigers also lost two-time Cy Young winner Tarik Skubal indefinitely due to elbow surgery.

Starting Pitchers

Skubal was scratched before Monday's scheduled start, and the Red Sox (14-21) took advantage with their third-most hits (12) of the season to win their third straight series opener. Jovani Moran (0-0, 2.33 ERA) is set to make his first MLB start for Boston, countered by Detroit's Framber Valdez (2-1, 3.35 ERA).

First pitch is at 6:40 p.m. ET from Comerica Park in Detroit. These teams have split their last 10 meetings.

Betting Odds

The latest Tigers vs. Red Sox odds have Detroit as -158 favorites (risk $158 to win $100), while the over/under for total runs is 8.5.

  • Money line: Tigers -158, Red Sox +133
  • Run line: Tigers -1.5 (+135), Red Sox +1.5 (-160)
  • Over/Under: 8.5 runs

Computer Model Prediction

The SportsLine Projection Model simulates every MLB game 10,000 times, and is coming off a 5-0 week on top-rated MLB picks. After 10,000 simulations of Red Sox vs. Tigers, the model is going Over 8.5 combined runs.

The last three matchups between these teams have all had at least 8 total runs, with Monday's meeting eclipsing the total. Boston will have Moran make his first MLB start, but he has a 4.52 ERA as a reliever since 2023. He's not expected to be on the mound long, and games that heavily involve a bullpen are ones that tend to be higher scoring.

As for Valdez, he's been solid in his first year in Detroit, but it's important to note that this is a night start for the former Astro. His ERA in night starts (4.13) is nearly three times that in day games (1.50). Both teams are projected to score more runs than what they average on the season, with the simulations calling for 9.9 combined runs scored.

The Over hits 62% of the time in over-under betting.

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