João Palhinha's 43rd-minute goal proved decisive as Tottenham sealed Premier League survival with a 1-0 home win over Everton.
Tottenham required a draw or victory to guarantee safety following their defeat at Chelsea on Tuesday. West Ham's result against Leeds would have no bearing on the north London club's destiny.
The victory ended a 10-match winless run at home in the Premier League and marked Tottenham's first home league win since December.
Match Details
Tottenham started strongly at the Tottenham Hotspur Stadium. With injured captain Cristian Romero present beside the dugout, Conor Gallagher fired wide after an early Everton corner.
The hosts continued to threaten from set-pieces. Pedro Porro's 50-50 challenge sparked noise, while Kevin Danso efforts caused panic in the Everton penalty area.
The decisive moment came in the 43rd minute. Mathys Tel delivered a dangerous corner, and Palhinha crashed a header against the post before reacting fastest to the rebound. His scuffed effort crept over the line before Thierno Barry could clear.
Nervy Second Half
A tense second half followed with news of West Ham taking the lead against Leeds filtering through. Everton boss David Moyes introduced Tyrique George and Harrison Armstrong.
Spurs manager De Zerbi made his first substitution, bringing on Randal Kolo Muani who lifted the ball over from 25 yards.
Spurs needed stand-in captain Micky van de Ven to intercept a dangerous cross by Everton substitute George before nine minutes of stoppage time were added.
Late Drama
In the ninth minute of stoppage time, George cut inside and let fly, but Antonin Kinsky produced a flying save to confirm victory.
The win ensured Tottenham avoided a first relegation in 49 years.